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KMID : 0606319930090010072
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Journal of Phamacetical Sciences Sookmyung Women s University
1993 Volume.9 No. 1 p.72 ~ p.0
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Pharmacokinetics of PtCl4(2-CEen) on after intraperitoneal administration to rabbits
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Abstract
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Abstract:
@EN The pharmacokinetics were compared after peritoneal administration of one of the new platinum species, PtCl4(2-CEen) and cisplatin, 5mg/kg, respectively, to rabbits by measuring the total platinum concentrations flameless atomic absorption
spectrometrically, following intraperitoneal(i.p.) injection of PtCl4(2-CEen), platinum levels reached maximum concentration of 1.6㎍/㎖at 12 hours andthen decreased slowly to 0.48㎍㎖at 5th day.
After i.p. administration, plasma concentrations of both total platinum of PtCl4(2-CEen) and cisplatin decayed biphasically. The rabbits treated with PtCl4(2-CEen) survived 5 days which is longer than 2 days treated with cisplatin. However, there
was no
significant differences of pharmacokinetic parameters between two treatments.
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KEYWORD
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